Publications
2026
Designing and Operating an In-House Cryogenic Electron Microscopy Facility: IT Infrastructure, Network Architecture, and On-the-Fly Data Processing Pipelines
JoVe (2026)
DOI: TBD
Diel remodeling and cellular integration of the nitroplast.
bioRxiv (2026)
DOI: https://doi.org/10.64898/2026.04.11.717942
Exploring Passive Permeability Profiles of Cyclic Heptapeptide Chemical Space Uncovers Bioactivity of Mortiamide Scaffold Driven by Colloidal Aggregation
Accepted in ChemBioChem (2026)
Human broadly neutralizing influenza B virus antibodies recognizing hemagglutinin computationally optimized broadly reactive antigens
Front. Immunol. (2026)
2025
Biological Breakthroughs and Drug Discovery Revolution via Cryo-Electron Microscopy of Membrane Proteins
Membranes (2025)
DOI: https://doi.org/10.3390/membranes15120368
Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis
bioRxiv (2025)
DOI: https://doi.org/10.1101/2025.10.24.684477
Assessing the structural boundaries of broadly reactive antibody interactions with diverse H3 influenza hemagglutinin proteins
Journal of Virology (2025)
DOI: https://doi.org/10.1128/jvi.00453-25
Structural mechanism for the recognition of E2F1 by the ubiquitin ligase adaptor Cyclin F
PNAS (2025)
DOI: https://doi.org/10.1073/pnas.2501057122
Structures of respiratory syncytial virus G bound to broadly reactive antibodies provide insights into vaccine design
Scientific Reports (2025)
DOI: https://doi.org/10.1038/s41598-025-08666
Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization
Journal of Virology (2025)
DOI: https://doi.org/10.1128/jvi.01619-24
Human calpain-3 and its structural plasticity: Dissociation of a homohexamer into dimers on binding titin
Journal of Biological Chemistry (2025)
DOI: https://doi.org/10.1016/j.jbc.2025
2024
High-resolution reconstruction of a C. elegans ribosome sheds light on evolutionary dynamics and tissue specificity
RNA (2024)
DOI: https://doi.org/10.1261/rna.079999.124
From Icy Specimens to Digital Insights: Integrating Sample Preparation, Data Analysis, and IT Infrastructure
Book chapter (2024)
DOI: https://doi.org/10.1201/978100
New insights into Hsp90 structural plasticity revealed by cryoEM
BioChem (2024)
DOI: https://doi.org/10.3390/biochem4020062
Amyloid-α peptide formed through alternative processing of the amyloid precursor protein attenuates Alzheimer’s amyloid-β toxicity via cross-chaperoning
JACS (2024)
DOI: https://doi.org/10.1021/jacs.3c14000
Bacterial selenocysteine synthase structure revealed by single-particle cryoEM
Current Research in Structural Biology (2024)
DOI: https://doi.org/10.1016/j.crstbi.2024.100143
2023 and Earlier
The Biomolecular cryo-EM Facility at UC Santa Cruz: What Should You Expect?
Protein Science (2023)
DOI: https://doi.org/10.1002/pro.4799
A frame-by-frame glance at membrane fusion mechanisms: from viral infections to fertilization
Biomolecules (2023)
DOI: https://doi.org/10.3390/biom13071130
Excitonically coupled simple coacervates via liquid/liquid phase separation
Journal of Physical Chemistry Letters (2022)
DOI: https://doi.org/10.1021/acs.jpclett.2c03075
Acknowledgement: We acknowledge the Biomolecular Cryo-Electron Microscopy Facility at the Department of Chemistry and Biochemistry of UCSC (RRID:SCR_021755) for scientific and technical assistance. Funding for the ThermoFisher Scientific Glacios TEM was supported by NIH S10OD02509.