UCSC Biomolecular Cryo-EM Facility

From sample to structure — high-resolution cryo-EM, cryo-ET, and MicroED with real-time processing and expert consulting.

Metrics Dashboard

🧊 20+ cryo-EM Maps Deposited
🎯 1.9–7.0 Å Resolution Range
👩‍🔬 65 Users Trained
💾 3+ PB Data Processed
20+ Publications
$21M+ Associated Funding

What We Offer

Single-Particle Cryo-EM

High-resolution structures of macromolecular complexes and membrane proteins.

Cryo-ET

In situ structural biology of cells, viruses, and pleomorphic systems.

MicroED

Atomic structures from nanocrystals with rapid screening workflows.

End-to-End Workflows

Sample Optimization → Grid Preparation → Data Collection → Real-Time Processing → Structure Determination

Access Modes

Full-Service
Assisted
Independent
Consulting
Flexible access for academia, national labs, and industry.

Infrastructure Highlight Strip

Glacios cryo-TEM
Plunge Freezing Suite featuring TFS Vitrobot Mark4+; Leica GP2 and manual plunger
GPU-based workstations (35+ available GPUs)
Automated Pipelines
Secure Multi-Petabyte Storage
Remote Processing

Acknowledgment

Copy-ready: We acknowledge the Biomolecular Cryo-Electron Microscopy Facility at the Department of Chemistry and Biochemistry of UCSC (RRID:SCR_021755) for scientific and technical assistance. Funding for the ThermoFisher Scientific Glacios TEM was supported by NIH S10OD02509.

Contact / Call to Action

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